.. _user-guide-appendix: Appendix ======== .. _table-vdw-parameters-tripos-52: .. table:: Van der Waals parameters in Tripos 5.2 force field (R = radius (Å); K = well depth (kcal/mol); IP = Ionization potential (eV); POL = polarisability (10\ :sup:`25` cm\ :sup:`3`)). +---------------+------+-------+-------+-------+----------------------------+ | Atom Type | R | K | IP | POL | Description | +===============+======+=======+=======+=======+============================+ | ``H`` | 1.5 | 0.042 | 13.6 | 4 | Non-polar hydrogen | +---------------+------+-------+-------+-------+----------------------------+ | ``H.P`` | 1.2 | 0.042 | 13.6 | 4 | Polar hydrogen | +---------------+------+-------+-------+-------+----------------------------+ | ``C.3`` | 1.7 | 0.107 | 14.61 | 13.8 | C sp3 (0 implicit H) | +---------------+------+-------+-------+-------+----------------------------+ | ``C.3.H1`` | 1.8 | 0.107 | 14.61 | 16.38 | C sp3 (1 implicit H) | +---------------+------+-------+-------+-------+----------------------------+ | ``C.3.H2`` | 1.9 | 0.107 | 14.61 | 19.27 | C sp3 (2 implicit H) | +---------------+------+-------+-------+-------+----------------------------+ | ``C.3.H3`` | 2 | 0.107 | 14.61 | 22.47 | C sp3 (3 implicit H) | +---------------+------+-------+-------+-------+----------------------------+ | ``C.2`` | 1.7 | 0.107 | 15.62 | 13.8 | C sp2 (0 implicit H) | +---------------+------+-------+-------+-------+----------------------------+ | ``C.cat`` | 1.7 | 0.107 | 15.62 | 13.8 | C sp2 (guanidinium centre) | +---------------+------+-------+-------+-------+----------------------------+ | ``C.2.H1`` | 1.8 | 0.107 | 15.62 | 16.38 | C sp2 (1 implicit H) | +---------------+------+-------+-------+-------+----------------------------+ | ``C.2.H2`` | 1.9 | 0.107 | 15.62 | 19.27 | C sp2 (2 implicit H) | +---------------+------+-------+-------+-------+----------------------------+ | ``C.ar`` | 1.7 | 0.107 | 15.62 | 13.8 | C aromatic (0 implicit H) | +---------------+------+-------+-------+-------+----------------------------+ | ``C.ar.H1`` | 1.8 | 0.107 | 15.62 | 16.38 | C aromatic (1 implicit H) | +---------------+------+-------+-------+-------+----------------------------+ | ``C.1`` | 1.7 | 0.107 | 17.47 | 13.8 | C sp (0 implicit H) | +---------------+------+-------+-------+-------+----------------------------+ | ``C.1.H1`` | 1.8 | 0.107 | 17.47 | 16.38 | C sp (1 implicit H) | +---------------+------+-------+-------+-------+----------------------------+ | ``N.4`` | 1.55 | 0.095 | 33.29 | 8.4 | N sp3+ (cationic) | +---------------+------+-------+-------+-------+----------------------------+ | ``N.3`` | 1.55 | 0.095 | 18.93 | 8.4 | N sp3 | +---------------+------+-------+-------+-------+----------------------------+ | ``N.pl3`` | 1.55 | 0.095 | 19.72 | 8.4 | N trigonal planar | | | | | | | (non-amide) | +---------------+------+-------+-------+-------+----------------------------+ | ``N.am`` | 1.55 | 0.095 | 19.72 | 8.4 | N trigonal planar (amide) | +---------------+------+-------+-------+-------+----------------------------+ | ``N.2`` | 1.55 | 0.095 | 22.1 | 8.4 | N sp2 | +---------------+------+-------+-------+-------+----------------------------+ | ``N.ar`` | 1.55 | 0.095 | 22.1 | 8.4 | N aromatic | +---------------+------+-------+-------+-------+----------------------------+ | ``N.1`` | 1.55 | 0.095 | 23.91 | 8.4 | N sp | +---------------+------+-------+-------+-------+----------------------------+ | ``O.3`` | 1.52 | 0.116 | 24.39 | 5.4 | O sp3 | +---------------+------+-------+-------+-------+----------------------------+ | ``O.2`` | 1.52 | 0.116 | 26.65 | 5.4 | O sp2 | +---------------+------+-------+-------+-------+----------------------------+ | ``O.co2`` | 1.52 | 0.116 | 35.12 | 5.4 | O carboxylate | +---------------+------+-------+-------+-------+----------------------------+ | ``S.3`` | 1.8 | 0.314 | 15.5 | 29.4 | S sp3 | +---------------+------+-------+-------+-------+----------------------------+ | ``S.o`` | 1.7 | 0.314 | 15.5 | 29.4 | sulfoxide | +---------------+------+-------+-------+-------+----------------------------+ | ``S.o2`` | 1.7 | 0.314 | 15.5 | 29.4 | sulfone | +---------------+------+-------+-------+-------+----------------------------+ | ``S.2`` | 1.8 | 0.314 | 17.78 | 29.4 | S sp2 | +---------------+------+-------+-------+-------+----------------------------+ | ``P.3`` | 1.8 | 0.314 | 16.78 | 40.6 | | +---------------+------+-------+-------+-------+----------------------------+ | ``F`` | 1.47 | 0.109 | 20.86 | 3.7 | | +---------------+------+-------+-------+-------+----------------------------+ | ``Cl`` | 1.75 | 0.314 | 15.03 | 21.8 | | +---------------+------+-------+-------+-------+----------------------------+ | ``Br`` | 1.85 | 0.434 | 13.1 | 31.2 | | +---------------+------+-------+-------+-------+----------------------------+ | ``I`` | 1.98 | 0.623 | 12.67 | 49 | | +---------------+------+-------+-------+-------+----------------------------+ | ``Na`` | 1.2 | 0.4 | | | | +---------------+------+-------+-------+-------+----------------------------+ | ``K`` | 1.2 | 0.4 | | | | +---------------+------+-------+-------+-------+----------------------------+ | ``UNDEFINED`` | 1.2 | 0.042 | | | | +---------------+------+-------+-------+-------+----------------------------+ .. _table-geometric-parameters-empirical-terms: .. table:: Geometrical parameters for empirical terms (a = Geometric variable; b = Ideal value; c = Tolerance on ideal value; d = Deviation at which score is reduced to zero). +--------------------------+-------------------------------------------+--------------+-------------------+-------------------+-----------------------------+ | Term | :math:`X`\ :sup:`a` | :math:`X_0`\ | :math:`X_{\min}`\ | :math:`X_{\max}`\ | Description | | | | :sup:`b` | :sup:`c` | :sup:`d` | | +==========================+===========================================+==============+===================+===================+=============================+ | :math:`S_{\text{polar}}` | :math:`R_{12}` | :math:`R` + | 0.25 Å | 0.6 Å | Distance between | | | | 0.05 Å | | | interaction centres | +--------------------------+-------------------------------------------+--------------+-------------------+-------------------+-----------------------------+ | | :math:`\alpha_{\text{DON}}` | 180° | 30° | 80° | Angle around donor H | +--------------------------+-------------------------------------------+--------------+-------------------+-------------------+-----------------------------+ | | :math:`\alpha_{\text{ACC}}` | 180° | 60° | 100° | Angle around acceptor | +--------------------------+-------------------------------------------+--------------+-------------------+-------------------+-----------------------------+ | | :math:`\alpha_{\text{C+}}` | 180° | 60° | 100° | Angle between C+ACC vector | | | | | | | and normal to plane of | | | | | | | guanidinium group | +--------------------------+-------------------------------------------+--------------+-------------------+-------------------+-----------------------------+ | | :math:`\phi_{\text{ACC}\_\text{LP}}` | 45° | 15° | 15° | From [RiboDock2004]_ | | | | | | | Figure 2. | +--------------------------+-------------------------------------------+--------------+-------------------+-------------------+-----------------------------+ | | :math:`\theta_{\text{ACC}\_\text{LP}}` | 0° | 20° | 60° | From [RiboDock2004]_ | | | | | | | Figure 2. | +--------------------------+-------------------------------------------+--------------+-------------------+-------------------+-----------------------------+ | | :math:`\phi_{\text{ACC}\_\text{PLANE}}` | 0° | 60° | 75° | From [RiboDock2004]_ | | | | | | | Figure 2. | +--------------------------+-------------------------------------------+--------------+-------------------+-------------------+-----------------------------+ | | :math:`\theta_{\text{ACC}\_\text{PLANE}}` | 0° | 20° | 60° | From [RiboDock2004]_ | | | | | | | Figure 2. | +--------------------------+-------------------------------------------+--------------+-------------------+-------------------+-----------------------------+ | :math:`S_{\text{repul}}` | :math:`R_{12}` | R + 1.1 Å | 0.25 Å | 0.6 Å | Distance between | | | | | | | interaction centres | +--------------------------+-------------------------------------------+--------------+-------------------+-------------------+-----------------------------+ | | :math:`\alpha_{\text{DON}}` | 180° | 30° | 60° | Angle around donor H | +--------------------------+-------------------------------------------+--------------+-------------------+-------------------+-----------------------------+ | | :math:`\alpha_{\text{ACC}}` | 180° | 30° | 60° | Angle around acceptor | +--------------------------+-------------------------------------------+--------------+-------------------+-------------------+-----------------------------+ | :math:`S_{\text{arom}}` | :math:`R_{\text{perp}}` | 3.5 Å | 0.25 Å | 0.6 Å | From [RiboDock2004]_ | | | | | | | Figure 3. | +--------------------------+-------------------------------------------+--------------+-------------------+-------------------+-----------------------------+ | | :math:`\alpha_{\text{slip}}` | 0° | 20° | 60° | From [RiboDock2004]_ | | | | | | | Figure 3. | +--------------------------+-------------------------------------------+--------------+-------------------+-------------------+-----------------------------+ .. _table-angular-functions-polar-interactions: .. table:: Angular functions used to describe attractive and repulsive polar interactions (a = Interaction centre types; b = angular functions in equations :eq:`(%s) `--:eq:`(%s) `). +---------------------+------------------------------------------+---------------------+------------------------------------------------------------------------------------------------------------+ | :math:`\text{IC1}`\ | :math:`\text{ANG}_{\text{IC1}}`\ | :math:`\text{IC2}`\ | :math:`\text{ANG}_{\text{IC2}}`\ :sup:`b` | | :sup:`a` | :sup:`b` | :sup:`a` | | +=====================+==========================================+=====================+============================================================================================================+ | **Attractive** (:math:`S_{\text{polar}}`) | +---------------------+------------------------------------------+---------------------+------------------------------------------------------------------------------------------------------------+ | DON | :math:`f_1(|\Delta\alpha_{\text{DON}}|)` | ACC_LP | :math:`f_1(|\Delta\phi_{\text{ACC}\_\text{LP}}|) \cdot f_1(|\Delta\theta_{\text{ACC}\_\text{LP}}|)` | +---------------------+------------------------------------------+---------------------+------------------------------------------------------------------------------------------------------------+ | DON | :math:`f_1(|\Delta\alpha_{\text{DON}}|)` | ACC_PLANE | :math:`f_1(|\Delta\phi_{\text{ACC}\_\text{PLANE}}|) \cdot f_1(|\Delta\theta_{\text{ACC}\_\text{PLANE}}|)` | +---------------------+------------------------------------------+---------------------+------------------------------------------------------------------------------------------------------------+ | DON | :math:`f_1(|\Delta\alpha_{\text{DON}}|)` | ACC | :math:`f_1(|\Delta\alpha_{\text{ACC}}|)` | +---------------------+------------------------------------------+---------------------+------------------------------------------------------------------------------------------------------------+ | M+ | 1 | ACC_LP | :math:`f_1(|\Delta\phi_{\text{ACC}\_\text{LP}}|) \cdot f_1(|\Delta\theta_{\text{ACC}\_\text{LP}}|)` | +---------------------+------------------------------------------+---------------------+------------------------------------------------------------------------------------------------------------+ | M+ | 1 | ACC_PLANE | :math:`f_1(|\Delta\phi_{\text{ACC}\_\text{PLANE}}|) \cdot f_1(|\Delta\theta_{\text{ACC}\_\text{PLANE}}|)` | +---------------------+------------------------------------------+---------------------+------------------------------------------------------------------------------------------------------------+ | M+ | 1 | ACC | :math:`f_1(|\Delta\alpha_{\text{ACC}}|)` | +---------------------+------------------------------------------+---------------------+------------------------------------------------------------------------------------------------------------+ | | 1 | ACC_LP | | +---------------------+------------------------------------------+---------------------+------------------------------------------------------------------------------------------------------------+ | C+ | :math:`f_1(|\Delta\alpha_{\text{C+}}|)` | ACC_PLANE | :math:`f_1(|\Delta\alpha_{\text{ACC}}|)` | +---------------------+------------------------------------------+---------------------+------------------------------------------------------------------------------------------------------------+ | | 1 | ACC | | +---------------------+------------------------------------------+---------------------+------------------------------------------------------------------------------------------------------------+ | **Repulsive** (:math:`S_{\text{repul}}`) | +---------------------+------------------------------------------+---------------------+------------------------------------------------------------------------------------------------------------+ | DON | :math:`f_1(|\Delta\alpha_{\text{DON}}|)` | DON | :math:`f_1(|\Delta\alpha_{\text{DON}}|)` | +---------------------+------------------------------------------+---------------------+------------------------------------------------------------------------------------------------------------+ | DON | :math:`f_1(|\Delta\alpha_{\text{DON}}|)` | M+ | 1 | +---------------------+------------------------------------------+---------------------+------------------------------------------------------------------------------------------------------------+ | DON | :math:`f_1(|\Delta\alpha_{\text{DON}}|)` | C+ | 1 | +---------------------+------------------------------------------+---------------------+------------------------------------------------------------------------------------------------------------+ | M+ | 1 | C+ | 1 | +---------------------+------------------------------------------+---------------------+------------------------------------------------------------------------------------------------------------+ | C+ | 1 | C+ | 1 | +---------------------+------------------------------------------+---------------------+------------------------------------------------------------------------------------------------------------+ | ACC_LP | | ACC_LP | | +---------------------+------------------------------------------+---------------------+------------------------------------------------------------------------------------------------------------+ | ACC_PLANE | :math:`f_1(|\Delta\alpha_{\text{ACC}}|)` | ACC_PLANE | :math:`f_1(|\Delta\alpha_{\text{ACC}}|)` | +---------------------+------------------------------------------+---------------------+------------------------------------------------------------------------------------------------------------+ | ACC | | ACC | | +---------------------+------------------------------------------+---------------------+------------------------------------------------------------------------------------------------------------+ .. _table-solvation-parameters: .. table:: Solvation parameters (a = Frequency of occurrence in training set). +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | Atom type | Description | :math:`N`\ | :math:`r_i` | :math:`p_i` | :math:`w_i` | | | | :sup:`a` | | | | +===============+===========================================+=============+=============+=============+=============+ | ``C_sp3`` | Apolar carbon sp3 with 0 implicit H | 48 | 1.7 | 2.149 | 0.8438 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``CH_sp3`` | Apolar carbon sp3 with 1 implicit H | 59 | 1.8 | 1.276 | 0.0114 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``CH2_sp3`` | Apolar carbon sp3 with 2 implicit H | 487 | 1.9 | 1.045 | 0.0046 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``CH3_sp3`` | Apolar carbon sp3 with 3 implicit H | 409 | 2 | 0.88 | 0.0064 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``C_sp2`` | Apolar carbon sp2 with 0 implicit H | 10 | 1.72 | 1.554 | 0.0789 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``CH_sp2`` | Apolar carbon sp2 with 1 implicit H | 45 | 1.8 | 1.073 | -0.0014 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``CH2_sp2`` | Apolar carbon sp2 with 2 implicit H | 26 | 1.8 | 0.961 | 0.0095 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``C_sp2p`` | Positive charged carbon sp2 | 2 | 1.72 | 1.554 | -0.7919 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``C_ar`` | Apolar aromatic carbon with 0 implicit H | 116 | 1.72 | 1.554 | 0.017 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``CH_ar`` | Apolar aromatic carbon with 1 implicit H | 357 | 1.8 | 1.073 | -0.0143 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``C_sp`` | Carbon sp | 24 | 1.78 | 0.737 | -0.0052 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``C_sp3_P`` | Polar carbon sp3 with 0 implicit H | 6 | 1.7 | 2.149 | -0.0473 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``CH_sp3_P`` | Polar carbon sp3 with 1 implicit H | 22 | 1.8 | 1.276 | -0.0394 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``CH2_sp3_P`` | Polar carbon sp3 with 2 implicit H | 130 | 1.9 | 1.045 | -0.0078 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``CH3_sp3_P`` | Polar carbon sp3 with 3 implicit H | 69 | 2 | 0.88 | 0.0033 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``C_sp2_P`` | Polar carbon sp2 with 0 implicit H | 57 | 1.72 | 1.554 | -0.2609 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``CH_sp2_P`` | Polar carbon sp2 with 1 implicit H | 30 | 1.8 | 0.961 | -0.005 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``CH2_sp2_P`` | Polar carbon sp2 with 2 implicit H | 1 | 1.8 | 0.961 | 0.0095 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``C_ar_P`` | Polar aromatic carbon with 0 implicit H | 53 | 1.72 | 1.554 | -0.2609 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``CH_ar_P`` | Polar aromatic carbon with 1 implicit H | 34 | 1.8 | 1.073 | -0.0015 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``H`` | Explicit apolar hydrogen (not used) | 0 | 1.2 | 1 | 0 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``HO`` | Polar hydrogen bonded to O | 54 | 1 | 0.944 | 0.0499 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``HN`` | Polar hydrogen bonded to N | 54 | 1.1 | 1.128 | -0.0242 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``HNp`` | Positively charged polar hydrogen bonded | 23 | 1.2 | 1.049 | -1.9513 | | | to N | | | | | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``HS`` | Polar hydrogen bonded to S | 4 | 1.2 | 0.928 | 0.0487 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``O_sp3`` | Ether oxygen | 31 | 1.52 | 1.08 | -0.138 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``OH_sp3`` | Alcohol/phenol oxygen | 48 | 1.52 | 1.08 | -0.272 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``O_tri`` | Ester oxygen | 59 | 1.52 | 1.08 | 0.0965 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``OH_tri`` | Acid oxygen (neutral) | 6 | 1.52 | 1.08 | -0.0985 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``O_sp2`` | Oxygen sp2 | 83 | 1.5 | 0.926 | -0.1122 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``ON`` | Nitro group oxygen | 18 | 1.5 | 0.926 | -0.0055 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``Om`` | Negatively charged oxygen (carboxylate | 7 | 1.7 | 0.922 | -0.717 | | | etc.) | | | | | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``N_sp3`` | Nitrogen sp3 with 0 attached H | 8 | 1.6 | 1.215 | -0.6249 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``NH_sp3`` | Nitrogen sp3 with 1 attached H | 11 | 1.6 | 1.215 | -0.396 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``NH2_sp3`` | Nitrogen sp3 with 2 attached H | 11 | 1.6 | 1.215 | -0.215 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``N_sp3p`` | Nitrogen sp3+ | 6 | 1.6 | 1.215 | -0.1186 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``N_tri`` | Amide nitrogen with 0 attached H | 15 | 1.55 | 1.028 | -0.23 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``NH_tri`` | Amide nitrogen with 1 attached H | 8 | 1.55 | 1.028 | -0.4149 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``NH2_tri`` | Amide nitrogen with 2 attached H | 6 | 1.55 | 1.028 | -0.1943 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``N_sp2`` | Nitrogen sp2 | 3 | 1.55 | 1.413 | -0.0768 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``N_sp2p`` | Nitrogen sp2+ | 5 | 1.55 | 1.413 | -0.2744 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``N_ar`` | Aromatic nitrogen | 26 | 1.55 | 1.413 | -0.531 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``N_sp`` | Nitrogen sp | 6 | 1.55 | 1 | -0.1208 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``S_sp3`` | Sulphur sp3 | 15 | 1.8 | 1.121 | -0.0685 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``S_sp2`` | Sulphur sp2 | 5 | 1.8 | 1.121 | -0.0314 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``P`` | Phosphorous | 10 | 1.8 | 1.589 | -1.275 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``F`` | Fluorine | 99 | 1.47 | 0.906 | 0.0043 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``Cl`` | Chlorine | 132 | 1.75 | 0.906 | -0.0096 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``Br`` | Bromine | 37 | 1.85 | 0.898 | -0.0194 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``I`` | Iodine | 9 | 1.98 | 0.876 | -0.0189 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``Metal`` | All metals | 0 | 0.7 | 1 | -1.6667 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+ | ``UNDEFINED`` | Undefined types | 0 | 1.2 | 1 | 0 | +---------------+-------------------------------------------+-------------+-------------+-------------+-------------+